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Contagion is a rune effect in Marked for Death, a Discipline-spending supplemental Demon Hunter skill.

This rune effect causes the ability to spread to other monsters if the first one targeted dies. The effect can chain repeatedly, potentially spreading to numerous enemies. The full 30 second timer appears to reset with each new target.

This effect is very useful against boss packs champions, or even regular monsters on higher difficulty levels.

Skill Rune Effects[edit]

See the Marked for Death rune effects page for thorough descriptions of all five rune effects in this skill, including screenshots, videos, and strategy tips.

Name Level Description
Marked for Death

1 Cost: 3 Discipline

Mark an enemy. The marked enemy takes 20% additional damage for the next 30 seconds.

MedRuneB Contagion
1 When the enemy is killed, the mark spreads to the closest 3 enemies within 30 yards. This effect can chain repeatedly.


Screenshots and movies will be added post-release.


Prior to the skill revision in February 2012, this rune effect was enabled by the Indigo Rune, granting the following effect with a level 7 runestone:



When the target is killed the ability spreads to 8 other nearby targets. This effect can chain repeatedly.