From Diablo Wiki
Confusion is a status effect in Diablo III. It operates similar to how it did in Diablo II, particularly the Necromancer's curse . The effect confuses the target, and the target(s) will not be able to tell friend from foe, attacking anything within range. This is a potentially nasty status effect if it works in PVP, but whether it does or not, or what effect it has in PVP, is currently unknown. The confuse effect is noted above a target's head with a blue swirl.
Known Skills Using Confuse
- Witch Doctor:
Counters and Immunities
A counter to confuse would be a skill or an ability that allows a player to remove or otherwise negate the effect. An immunity would allow the player to never be afflicted.