Chemical Burn


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Chemical Burn is a rune effect in Impale, a Hatred-spending Demon Hunter skill.

This rune effect retains the base skill effect, and also causes the target to bleed for 125% weapon damage over 2 seconds. This is a quite damaging attack, dealing a total of 375% damage over the full duration. Alternating this with a Hatred-generator can nearly replace the full cost of using it, during the bleeding time.

Skill Rune Effects[edit]

See the Impale rune effects page for a thorough description of all five rune effects in this skill, including screenshots, videos, and strategy tips.

Name Level Description

1 Cost: 20 Hatred

Throw a knife that impales an enemy for 750% weapon damage.

MedRuneC Chemical Burn
1 The enemy also burns for 500% weapon damage as Fire over 2 seconds.


Screenshots and videos will be added post-release.


Prior to the February 2012 skill and rune system overview, this effect was granted by the Indigo Rune, which created the following effect (with a level seven rune):

Liquid Flame


Fire an explosive shell that deals an additional 275% weapon damage over 2 seconds.